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Drug Discovery & Development

Mast Therapeutics announces new data supporting MST-188 in sickle cell disease Mast Therapeutics has announced that, in an ex vivo study conducted at Loyola University Medical Center, MST-188 reduced the mean erythrocyte sedimentation rate (ESR) by 50% relative to control in blood collected from individuals with sickle cell disease.
Drug Research > Drug Discovery & Development > News
Ipsen presents first set of results on Phase III clinical study of Dysport By PBR Staff Writer
Ipsen has reported the first set of results on Phase III clinical study of Dysport, an injectable form of botulinum toxin type A (BoNT-A), in the treatment of adults suffering from upper limb spasticity at the 8th World Congress for NeuroRehabilitation in Istanbul, Turkey.
Drug Research > Drug Discovery & Development > News Assembly Pharmaceuticals, BioCrossroads to advance potentially curative therapy for chronic hepatitis b virus Assembly Pharmaceuticals and BioCrossroads have announced that the BioCrossroads Indiana Seed Fund II has made an investment in Assembly Pharmaceuticals.
Drug Research > Drug Discovery & Development > News
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Oricula Therapeutics secures initial funding from University of Washington
Oricula Therapeutics, a biotech company, has announced that it has secured initial funding and licensed intellectual property from University of Washington.
Drug Research > Drug Discovery & Development > News
Spero Therapeutics announces antibiotics collaboration with Roche
By PBR Staff Writer
US-based biopharmaceutical company Spero Therapeutics has announced antibiotics collaboration with Switzerland-based F. Hoffmann-La Roche.
Drug Research > Drug Discovery & Development > News
Mimetix Scaffolds for 3D Cell Culture and Tissue Engineering
Electrospun scaffolds are highly porous and mimic the extracellular matrix, providing an ideal environment to support the growth of cells in 3D. They are created by electrospinning polymers into nanofibres or microfibres. Xeno-free, FDA-approved, medical grade polymers can be selected to facilitate translation of research findings into clinical use.
Drug Research > Drug Discovery & Development > Case Studies
Mimetix Scaffolds for 3D Cell Culture and Drug Discovery
Cells grown in a 3D micro-environment look and behave more like cells in human tissues than those cultured in 2D. They are in contact with other cells and produce extracellular matrix, which influences tissue-specific gene expression, cell growth and the uptake and metabolism of drugs. 3D cell-based in vitro assays can provide more realistic data on the efficacy of drug candidates against tumour cells or their toxicity, potentially reducing the risk of failure in expensive clinical trials.
Drug Research > Drug Discovery & Development > Case Studies
Mimetix® Electrospun Scaffolds for 3D Culture of Upcyte® and Primary Hepatocytes
This study investigates the Mimetix® electrospun scaffold, which consists of highly uniform electrospun PLLA microfibres supporting the three-dimensional growth of cells, as a cell-based assay system for upcyte® and primary hepatocytes.
Drug Research > Drug Discovery & Development > Case Studies
Mimetix for 3D Culture Human Epithelial Breast Cancer Cells
The objective of this study was to test if the Mimetix® electrospun scaffold is a suitable tool for the culture of human epithelial breast cancer cells in 3D, which can be used in drug discovery programmes for in vitro toxicity and efficacy assays. Cell viability and growth in 12-well plates and 96-well plates was shown to be highly consistent (cv < 10%) and cells were shown to be more resistant to drug-induced apoptosis following 10 days of proliferation in the Mimetix scaffolds than on 2D tissue culture plastic, indicating that they had assumed a 3D phenotype.
Drug Research > Drug Discovery & Development > Case Studies
Well-Plates with Removable Scaffolds
Our Mimetix® 6-well hanging-insert format allows for cells to be cultured with an air-liquid interface or with exposure to medium from above and below.
Drug Research > Drug Discovery & Development > Products
3D Cell Platform: Mimetix 96-Well Plate
The Mimetix® 96-well plate, our highly consistent and easy-to-use 3D platform, holds great promise to reduce the number of costly drug failures in clinical trials by enabling more realistic tumour and toxicology models.
Drug Research > Drug Discovery & Development > Products
Bespoke Cell Scaffold Solutions
We can customise scaffold material, architecture and shape to suit your specific application.
Drug Research > Drug Discovery & Development > Products
Glycotope - Optimising the Glycosylation of Biopharmaceuticals
Glycotope Biotechnology offers GMP-compliant biotechnological contract manufacturing, based on animal cell culture systems in fed-batch or perfusion fermentation technologies. The Company is compliant with all criteria within the European Pharmaceutical legislation, the European Pharmacopoeia, as well as EU and ICH guidelines.
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