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Drug Discovery & Development

DNDi, Takeda to develop new treatment for visceral leishmaniasis By PBR Staff Writer
Switzerland-based Drugs for Neglected Diseases initiative (DNDi) and Takeda Pharmaceutical have signed an agreement to collaborate in the 'Lead Optimization Program' to discover the best compound among aminopyrazole series for developing a new treatment for visceral leishmaniasis (VL).
Drug Research > Drug Discovery & Development > News
China's Yabao and Lawson complete discovery validation work of annexin A5-based products By PBR Staff Writer
China-based Yabao Pharmaceutical and Lawson Health Research Institute (Lawson) have completed the discovery validation work of products based on annexin A5 and moved the program into preclinical development.
Drug Research > Drug Discovery & Development > News Invion, Hovione sign joint development and licensing deal for inhaled Zafirlukast Australian drug development company Invion has secured a commitment from Hovione Scientia Limited, an international pharmaceutical company expert in inhalation development and manufacturing, to progress development of inhaled INV104 (zafirlukast) as a potential new treatment for asthma.
Drug Research > Drug Discovery & Development > News
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Truly Parallel - Cell Culture
| By Eppendorf
DASGIP® Bioreactor Systems for Cell Culture Applications.
Drug Research > Drug Discovery & Development > White Papers
Product Brochure: Most Compact
| By Eppendorf
DASbox® Mini Bioreactor System for Cell Culture and Microbiology.
Drug Research > Drug Discovery & Development > White Papers
Invion, Hovione sign joint development and licensing deal for inhaled Zafirlukast
Australian drug development company Invion has secured a commitment from Hovione Scientia Limited, an international pharmaceutical company expert in inhalation development and manufacturing, to progress development of inhaled INV104 (zafirlukast) as a potential new treatment for asthma.
Drug Research > Drug Discovery & Development > News
Eddingpharm to begin Phase I trial of Brinavess in China
By PBR Staff Writer
Eddingpharm, the Chinese development and commercialization partner of Cardiome Pharma, is planning to start a Phase I trial of Brinavess to support regulatory approval in China.
Drug Research > Drug Discovery & Development > News
Erytech reports positive results from Phase II trial of ERY-ASP in pancreatic cancer patients
By PBR Staff Writer
French biopharmaceutical firm Erytech Pharma has reported positive results from a Phase II trial of its lead product candidate ERY-ASP in patients with pancreatic cancer.
Drug Research > Drug Discovery & Development > News
Bristol-Myers's Phase III RCC trial of Opdivo shows superior overall survival over everolimus
By PBR Staff Writer
Bristol-Myers Squibb has stopped a Phase III trial (CheckMate -025) evaluating Opdivo (nivolumab) versus everolimus in previously-treated patients with advanced or metastatic renal cell carcinoma (RCC).
Drug Research > Drug Discovery & Development > News
Achaogen gets $4.5m NIAID contract to develop new LpxC inhibitors to treat bacterial infections
Achaogen, a clinical-stage biopharmaceutical company developing novel antibacterials to treat multi-drug resistant (MDR) gram-negative infections, announced it has been awarded a contract for $1.5m over the next year, with additional funding up to $3m available over the next three years if all options are exercised.
Drug Research > Drug Discovery & Development > News
All-Purpose Protein Sample QC Using a Novel Micro-Volume Platform with Spectral Content Profiling Software
| By Trinean
Accurate total protein quantitation of purified proteins, cell lysates, affinity-column fractions or other complex protein samples is crucial for robust biochemical testing during biopharmaceutical development as well as production. As the presence of chemicals doesn't allow simple A280 protein quantification, more labor-intensive alternatives for quantification are used. Examples are the colorimetric Bradford or BCA assay, which negate to a large extent the presence of contaminants but require multiple steps and show variation depending on the sample composition and time point of measuring within the ongoing reaction.
Drug Research > Drug Discovery & Development > White Papers
Precise Nucleic Acid Quantification Using Lab-on-a-chip Spectroscopy and the cDrop Quantification Algorithm
| By Trinean
Precise quantification and quality control of isolated genomic DNA is critical for the success of downstream applications such as next-generation sequencing. Traditionally, two quantification methods have been used routinely: (1) UV/Vis spectroscopy and (2) fluorescence-based assays (i.e. PicoGreen) that utilize DNA intercalating agents.
Drug Research > Drug Discovery & Development > White Papers
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