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1-15 of 5016 results
Avexxin completes Phase I/IIa trial of AVX001 in psoriasis
Avexxin, a therapeutic company focusing on the discovery and development of novel small molecule therapeutics for patients suffering from chronic inflammatory conditions, announces the completion of a second phase I/IIa study showing Proof-of-Concept in man.
Drug Research > Drug Discovery & Development > News
Biogen and AGTC join forces to develop gene therapies in ophthalmology
Biogen (BIIB) and AGTC have established collaboration and license agreement to develop gene-based therapies for multiple ophthalmic diseases.
Drug Research > Drug Discovery & Development > News
Kite Pharma join forces with Leukemia & Lymphoma Society
Kite Pharma and the Leukemia & Lymphoma Society (LLS) have entered into a partnership to enhance the development of Kite's lead product candidate, KTE-C19, for the treatment of patients with refractory aggressive non-Hodgkin lymphoma (NHL).
Drug Research > Drug Discovery & Development > News
Evaluation of the BioFlo® 320 Process Capabilities
| By Eppendorf
This poster characterizes the capabilities of the BioFlo320 in terms of key process parameters including oxygen transfer rate (OTR), volumetric mass transfer coecient (kLa), tip speed, mixing time, and water consumption. These data enable quantitative analyses of bioprocess engineering parameters, thus allowing potential users to gain insight into the system’s cell culture and fermentation capabilities.
Drug Research > Drug Discovery & Development > White Papers
Taking the Strain
| By Eppendorf
Today, the rapidly expanding demand for vaccine products for viral diseases such as rabies has necessitated the development of more sophisticated production techniques based around cell culture systems. This article reviews vaccine production strategies, with a focus on rabies, looking specifically at the use of the Vero cell line - used worldwide and approved by the US Food and Drug Administration - as well as media technology and the bioreactor options available.
Drug Research > Drug Discovery & Development > White Papers
Spyryx gets development award to advance novel therapy for cystic fibrosis
By PBR Staff Writer
US-based biopharmaceutical firm Spyryx Biosciences has received an award from Cystic Fibrosis Foundation Therapeutics, which will support development of its therapeutic peptides for cystic fibrosis (CF).
Drug Research > Drug Discovery & Development > News
Barda exercises $3m in additional contract funding to develop Aeolus' AEOL 10150 to treat acute radiation syndrome
Aeolus Pharmaceuticals, a biotechnology company developing compounds to protect against radiological and chemical threats in partnership with the US Government, announced that the Biomedical Advanced Research and Development Authority (BARDA) exercised $3m in additional contract options under its advanced research and development contract for AEOL 10150.
Drug Research > Drug Discovery & Development > News
Immunovaccine, Incyte to evaluate new immunotherapy combination to treat platinum-sensitive ovarian cancer
By PBR Staff Writer
Immunovaccine has entered into a non-exclusive clinical trial collaboration with Incyte to evaluate the combination of DPX-Survivac and epacadostat in patients with platinum-sensitive ovarian cancer.
Drug Research > Drug Discovery & Development > News
Aquinox releases positive results from Phase II trial with AQX-1125 to treat BPS/IC
Aquinox Pharmaceuticals (Aquinox) has announced results from its Phase II LEADERSHIP randomized clinical trial investigating the therapeutic potential of AQX-1125 in treating pain in patients with bladder pain syndrome/interstitial cystitis (BPS/IC).
Drug Research > Drug Discovery & Development > News
Vaccinex starts Phase II trial of VX15/2503 antibody to treat Huntington's disease
By PBR Staff Writer
US-based clinical-stage immunotherapy firm Vaccinex has started a Phase II clinical trial (SIGNAL) of anti-semaphorin 4D antibody VX15/2503 (VX15) for the treatment of patients with Huntington's disease (HD).
Drug Research > Drug Discovery & Development > News
ObsEva begins enrollment in Phase II TERM trial of OBE001 in pregnant women with preterm labor
ObsEva, a Swiss biopharmaceutical company developing a novel generation of drugs addressing serious conditions compromising pregnancy from conception to birth, announced the recruitment of the first patient in the TERM study, a Phase II clinical trial in pregnant women with preterm labor of its lead compound OBE001, an orally active oxytocin receptor antagonist.
Drug Research > Drug Discovery & Development > News
Amgen reports positive results from Phase II trial of AMG 334 to prevent migraine
By PBR Staff Writer
Amgen has reported positive interim results from its open-label extension of the global Phase II trial evaluating the safety and efficacy of AMG 334 for the prevention of episodic migraine.
Drug Research > Drug Discovery & Development > News
Epizyme reports positive data from Phase I trial of tazemetostat to treat non-hodgkin lymphoma
Epizyme, a clinical stage biopharmaceutical company creating novel epigenetic therapeutics for cancer patients, today reported results from the ongoing phase 1 trial of tazemetostat (EPZ-6438), a first-in-class EZH2 inhibitor, showing meaningful clinical activity when used as an oral monotherapy in patients with advanced B-cell non-Hodgkin lymphomas (NHL) and solid tumors.
Drug Research > Drug Discovery & Development > News
Akashi reports positive clinical data on HT-100 in DMD patients
Akashi Therapeutics a clinical stage biopharmaceutical company developing treatments for Duchenne muscular dystrophy (DMD), announced positive interim clinical data from an ongoing Phase 1b/2a clinical program with HT-100 (delayed-release halofuginone) an orally available, small molecule developed to reduce fibrosis and inflammation and promote healthy muscle fiber regeneration in boys with DMD.
Drug Research > Drug Discovery & Development > News
Atopix gets funding to broaden development of CRTH2 antagonists for TH2-mediated disease
Atopix Therapeutics Limited (Atopix), a UK biopharmaceutical company developing a novel class of medicines to treat atopic dermatitis and severe asthma, announced that it has raised additional development capital to advance its lead product OC459 for the treatment of asthma.
Drug Research > Drug Discovery & Development > News

PBR Supplier Recommendations

Therapure Biopharma - Contract Protein Development and Manufacturing
Therapure Biopharma is a Contract Development and Manufacturing Organization (CDMO) that specializes in the development, scale up and manufacture of complex biologics. ... Drug Research > Drug Discovery & Development > Suppliers
Vetter Pharma International - High-Quality Aseptically Pre-Filled Injection Systems
From preclinical development through commercial supply.... Drug Research > Drug Discovery & Development > Suppliers
ERT - Getting it done. Right.
ERT is a leading global provider of high-quality patient safety and efficacy endpoint data collection solutions for use by biopharmaceutical companies during clinical drug development. ERT delivers a combination of technology, services, and consulting that increase the accuracy and reliability of patient data and improve the efficiency of the clinical development process throughout the product lifecycle.... Drug Research > Drug Discovery & Development > Suppliers
Eppendorf - We Know Bioprocessing
Eppendorf is a leading life science company that develops and sells instruments, consumables, and services for liquid-, sample-, and cell handling in laboratories worldwide. Its product range includes pipettes and automated pipetting systems, dispensers, centrifuges, mixers, spectrometers, and DNA amplification equipment as well as ultra-low temperature freezers, fermentors, bioreactors, CO² incubators, shakers, and cell manipulation systems. Consumables such as pipette tips, test tubes, microtiter plates, and disposable bioreactors complement the range of highest-quality premium products.... Drug Research > Drug Discovery & Development > Suppliers
Biovian - cGMP Contract Manufacturing of Biopharmaceuticals
Biovian is a dynamic and effective new generation one-stop-shop CMO in cGMP contract manufacturing of biopharmaceuticals. Biovian's services cover the full range from antigen isolation, expression, vector construction, cell line cultivation, cGMP protein purification to product fill and finish.... Drug Research > Drug Discovery & Development > Suppliers
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PBR White Paper Recommendations

Evaluation of the BioFlo® 320 Process Capabilities By Eppendorf
This poster characterizes the capabilities of the BioFlo320 in terms of key process parameters including oxygen transfer rate (OTR), volumetric mass transfer coecient (kLa), tip speed, mixing time, and water consumption. These data enable quantitative analyses of bioprocess engineering parameters, thus allowing potential users to gain insight into the system’s cell culture and fermentation capabilities.... Drug Research > Drug Discovery & Development > White Papers Taking the Strain By Eppendorf
Today, the rapidly expanding demand for vaccine products for viral diseases such as rabies has necessitated the development of more sophisticated production techniques based around cell culture systems. This article reviews vaccine production strategies, with a focus on rabies, looking specifically at the use of the Vero cell line - used worldwide and approved by the US Food and Drug Administration - as well as media technology and the bioreactor options available.... Drug Research > Drug Discovery & Development > White Papers Growing Potential: mAb Production With Fibra-Cel By Eppendorf
The market for monoclonal antibodies continues to grow steadily, but there are still bottlenecks in the development of new products, including long development times mostly due to R&D. Advanced bioprocess equipment that meets the specific demands of mAb-producing hybridoma can accelerate design and production, and reduce overall development costs along the way.... Drug Research > Drug Discovery & Development > White Papers DoE Bioprocess Development By Eppendorf
Eppendorf DASware is the effective route to design of experiments (DoE) in early-stage bioprocess development. Claudia M Huether-Franken and Sebastian Kleebank explain how the design software applies DoE to DASGIP parallel bioreactor systems.... Drug Research > Drug Discovery & Development > White Papers Designing Wellness for Fun and Satisfaction: Gummies - Based Nutrition By Softigel pbr
The gummy delivery form for vitamins, minerals and supplements is the single-largest source of growth among the supplements category. Vitamin users report preference for gummy/soft chewable products because these offer not only pleasure and a fun experience, but efficacy and convenience. The selection of materials during the design process of the formula is critical for the final product in order to meet the expectations of the consumers, which is to find a healthy product that will give them a delicious reward as well. Based on the design and development process, this paper reviews review in detail the stage of selection of materials and validation as a critical phase to obtain a product that represents quality and stability as well as the specific requirements of the costumers and the consumers.... Drug Research > Drug Discovery & Development > White Papers See more
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