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New research to offer design to develop diabetes, cardiovascular drugs

PBR Staff Writer Published 07 June 2011

A research project at the University of Leicester aims to contribute to the design of novel drugs for the treatment of diabetes and cardiovascular diseases.

A PhD student with the Department of Cardiovascular Sciences Hussein Rubaiy analyzed the mechanisms of a cardiac potassium channel and its component parts, which play an important role in such vital processes as heart rhythm and tissue protection.

The study has provided information on how the channel works and how information from drug interaction is converted into modified function.

Rubaiy said he is optimistic that his detailed findings will find application in the pharmaceutical industry in the design or improvement of drugs for the treatment of type 2 diabetes and cardiovascular diseases.

Department of Cardiovascular Sciences senior lecturer Bob Norman said Rubaiy's findings add significantly to their understanding of how these channels work and hopefully should contribute in the future to the more rational design of drugs to modify the properties of this important drug target.