Drug Research
Drug Discovery & Development

Efficient SEC-UV-RI-MALS Analysis of Protein Aggregates

Published 09 May 2012 | By Tosoh Bioscience

Static light scattering in combination with size exclusion chromatography is a valuable tool for verifying purity of monoclonal antibodies (MABS) as such or as a quick check while the downstream processing takes place. Besides fluorescence detection, light scattering is one of the most sensitive methods to detect protein aggregates.

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Efficient SEC-UV-RI-MALS Analysis of Protein Aggregates