Drug Research
Drug Discovery & Development

HILIC–MS - High Resolution and Sensitivity for the Analysis of Very Polar Compounds

Published 08 May 2012 | By Tosoh Bioscience

Hydrophilic interaction liquid chromatography (HILIC) offers unique advantages for mass spectrometric detection of very polar compounds when compared to reversed phase chromatography. The higher organic content of the eluent in HILIC supports efficient evaporation of the solvent, thus enhancing sensitivity and altering ion suppression.

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HILIC–MS - High Resolution and Sensitivity for the Analysis of Very Polar Compounds