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Drug Discovery & Development White Papers

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16-30 of 140 results
1.20 Quantification of His-tagged IgG antibodies after IMAC Ni-column purification
| By Trinean
Trinean introduces a new cDrop™ application suited for the quantification (OD280) of IgG antibodies and derivatives like Fab fragments during purification by IMAC Ni-columns using imidazole-containing buffers.
Drug Research > Drug Discovery & Development > White Papers
Dye-free quantification of Oragene®/saliva DNA extracts using the Trinean DropSense96® Droplet Reader and cDrop™ Spectral Analysis Software
| By Trinean
Saliva samples collected with Oragene® self-collection kits from DNA Genotek offer a non-invasive and proven method for accessing high quality and quantity DNA for genomic testing and analysis. Proper quantification of the extracted DNA is a critical step for most downstream applications. Trinean has developed a specific quantification protocol for DNA from Oragene/saliva samples using the DropSense96® droplet reader and the cDrop™ spectral decomposition software. A comparative analysis using a PicoGreen® fluorescent quantification assay shows a comparable specificity for dsDNA quantification. Since the read-out of 96 samples with the DropSense96 is performed in 5 minutes without any prior mixing or incubation, this technology is a viable alternative to fluorescent quantification assays.
Drug Research > Drug Discovery & Development > White Papers
1.17 Maxwell®16 Blood purification Kit App and Maxwell®16 LEV Blood DNA Kit App
| By Trinean
A spectral content profiling application on the cDrop™ software is available for quantification and contamination analysis of DNA isolations from blood using the Maxwell® 16 Blood DNA purification Kit and The Maxwell®16 LEV Blood DNA Kit. In this note we describe how to use this application and how to export and interpret the results.
Drug Research > Drug Discovery & Development > White Papers
1.7 Quantifying Amplicons in Non-Purified PCR Reactions: Direct Assessment of Product Yield
| By Trinean
The polymerase chain reaction (PCR) is a fundamental tool in molecular biology and clinical testing. Most genetic tests rely upon the power of PCR to enrich specific target-sequences prior to analysis. Analytical methods like sequencing are relatively expensive and labs want to minimize the resources spent on samples that don't meet the requirements of concentration and quality to deliver a reliable result.
Drug Research > Drug Discovery & Development > White Papers
1.19 Qiagen® EZ1 Tissue DNA app
| By Trinean
A spectral content profiling application on the cDrop™ software is available for quantification and contamination analysis of DNA isolations from cells using the Qiagen® EZ1 Tissue DNA kit. In this note we describe how to use this application and how to export and interpret the results.
Drug Research > Drug Discovery & Development > White Papers
1.10 cDrop Protocol for TRIzol RNA Extract Quantification and Content QC
| By Trinean
This cDrop protocol is developed for specific RNA quantification of extracts from a variety of sample origins (human, animal, plant) using extraction kits based on the one-step extraction method using a guanidinium thiocyanate-phenol- chloroform reagent-mix developed by Chomczynski (1). Commercial available variants include the TRIzol® kit (Invitrogen), TRI Reagent® (MRC), RNAzolTM (MRC) and RNA STAT-60TM (Tel-Test).
Drug Research > Drug Discovery & Development > White Papers
Sciences Radiolabelling Brochure
| By Almac
Trust Almac with your 14C radiolabelling requirements and we will offer advice on the most appropriate label position for your molecule, including synthetic feasibility and metabolic stability.
Drug Research > Drug Discovery & Development > White Papers
Commerical Packaging
| By Almac
- Complementary US and UK operations, - Quality-driven, flexible packaging solutions, - Market leader for product launch of niche / orphan drug products, - Solid oral dose and biopharmaceutical packaging, - Packaging and artwork design, - Full serialisation and 2D matrix barcoding solutions.
Drug Research > Drug Discovery & Development > White Papers
Providing an Unparalleled Range of Contract Pharmaceutical Development and Manufacturing Services Globally for Over 40 Years
| By Almac
Only we can combine the expertise from our range of specialised services to provide you with the right solutions to help you develop and commercialise your products.
Drug Research > Drug Discovery & Development > White Papers
Building the Next Generation IRT: An Exclusive Look Under the Hood of IXRS®3
| By Almac
Interactive Response Technology (IRT) systems - used to manage patient interactions and drug supplies during clinical trials - perform a range of functions for sponsors, drug depots, and investigative sites. Yet, they are typically viewed by sponsors as a "painful necessity" rather than as a welcome, invaluable tool. That perception exists because the underlying technology is outmoded, and the user's experience is stuck in the pre-Internet era. While established systems are "tried and true" in that they have supported thousands of clinical trials over the years, they can also be tired and cumbersome.
Drug Research > Drug Discovery & Development > White Papers
Introducing Direct to Patient Shipments
| By Almac
Almac will ship the Clinical Trial Material (CTM) to participating clinical sites, where the drug is to be stored. Both shipping and storage of the CTM will follow standard procedures. Sites will interact with the Interactive Response Technology (IRT) provider in the usual way to obtain a kit assignment.
Drug Research > Drug Discovery & Development > White Papers
Truly Parallel - Cell Culture
| By Eppendorf
DASGIP® Bioreactor Systems for Cell Culture Applications.
Drug Research > Drug Discovery & Development > White Papers
Product Brochure: Most Compact
| By Eppendorf
DASbox® Mini Bioreactor System for Cell Culture and Microbiology.
Drug Research > Drug Discovery & Development > White Papers
16-30 of 140 results