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Drug Discovery & Development

Drug Discovery & Development White Papers

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31-45 of 149 results
Sciences Radiolabelling Brochure
| By Almac
Trust Almac with your 14C radiolabelling requirements and we will offer advice on the most appropriate label position for your molecule, including synthetic feasibility and metabolic stability.
Drug Research > Drug Discovery & Development > White Papers
Commerical Packaging
| By Almac
- Complementary US and UK operations, - Quality-driven, flexible packaging solutions, - Market leader for product launch of niche / orphan drug products, - Solid oral dose and biopharmaceutical packaging, - Packaging and artwork design, - Full serialisation and 2D matrix barcoding solutions.
Drug Research > Drug Discovery & Development > White Papers
Providing an Unparalleled Range of Contract Pharmaceutical Development and Manufacturing Services Globally for Over 40 Years
| By Almac
Only we can combine the expertise from our range of specialised services to provide you with the right solutions to help you develop and commercialise your products.
Drug Research > Drug Discovery & Development > White Papers
Building the Next Generation IRT: An Exclusive Look Under the Hood of IXRS®3
| By Almac
Interactive Response Technology (IRT) systems - used to manage patient interactions and drug supplies during clinical trials - perform a range of functions for sponsors, drug depots, and investigative sites. Yet, they are typically viewed by sponsors as a "painful necessity" rather than as a welcome, invaluable tool. That perception exists because the underlying technology is outmoded, and the user's experience is stuck in the pre-Internet era. While established systems are "tried and true" in that they have supported thousands of clinical trials over the years, they can also be tired and cumbersome.
Drug Research > Drug Discovery & Development > White Papers
Introducing Direct to Patient Shipments
| By Almac
Almac will ship the Clinical Trial Material (CTM) to participating clinical sites, where the drug is to be stored. Both shipping and storage of the CTM will follow standard procedures. Sites will interact with the Interactive Response Technology (IRT) provider in the usual way to obtain a kit assignment.
Drug Research > Drug Discovery & Development > White Papers
Truly Parallel - Cell Culture
| By Eppendorf
DASGIP® Bioreactor Systems for Cell Culture Applications.
Drug Research > Drug Discovery & Development > White Papers
Product Brochure: Most Compact
| By Eppendorf
DASbox® Mini Bioreactor System for Cell Culture and Microbiology.
Drug Research > Drug Discovery & Development > White Papers
All-Purpose Protein Sample QC Using a Novel Micro-Volume Platform with Spectral Content Profiling Software
| By Trinean
Accurate total protein quantitation of purified proteins, cell lysates, affinity-column fractions or other complex protein samples is crucial for robust biochemical testing during biopharmaceutical development as well as production. As the presence of chemicals doesn't allow simple A280 protein quantification, more labor-intensive alternatives for quantification are used. Examples are the colorimetric Bradford or BCA assay, which negate to a large extent the presence of contaminants but require multiple steps and show variation depending on the sample composition and time point of measuring within the ongoing reaction.
Drug Research > Drug Discovery & Development > White Papers
Precise Nucleic Acid Quantification Using Lab-on-a-chip Spectroscopy and the cDrop Quantification Algorithm
| By Trinean
Precise quantification and quality control of isolated genomic DNA is critical for the success of downstream applications such as next-generation sequencing. Traditionally, two quantification methods have been used routinely: (1) UV/Vis spectroscopy and (2) fluorescence-based assays (i.e. PicoGreen) that utilize DNA intercalating agents.
Drug Research > Drug Discovery & Development > White Papers
Sample Processing for the UK Biobank Genotyping Project
| By Trinean
A project was initiated in 2013 to perform SNP genotyping on all UK Biobank participants. The aim of the project (which was to be completed within an 18-24 month timeframe) was to generate high quality genotype data and to make these data available for researchers, via the UK Biobank Showcase system. This poster describes the sample processing workflow, presents a comparison between the two quantification methods used in the project (Trinean DropSense® 96 and PicoGreen) and provides a summary of the genotyping metrics for the (approx.) first 180,000 samples analysed.
Drug Research > Drug Discovery & Development > White Papers
Droplet UV/VIS Quantification of Native Proteins in Biopharmaceutical Processing
| By Trinean
Biopharmaceuticals are mainly produced by microbial fermentation or in animal cell cultures. As a consequence, a cascade of procedures including purification and characterization are required throughout the processing chain to obtain the protein at the desired level of purity and potency. Within these processes, quantification of the protein of interest is mandatory at critical steps to maintain confidence in the processing results and fidelity in the end product.
Drug Research > Drug Discovery & Development > White Papers
Evaluation of the BioFlo® 320 Process Capabilities
| By Eppendorf
This poster characterizes the capabilities of the BioFlo320 in terms of key process parameters including oxygen transfer rate (OTR), volumetric mass transfer coecient (kLa), tip speed, mixing time, and water consumption. These data enable quantitative analyses of bioprocess engineering parameters, thus allowing potential users to gain insight into the system’s cell culture and fermentation capabilities.
Drug Research > Drug Discovery & Development > White Papers
Taking the Strain
| By Eppendorf
Today, the rapidly expanding demand for vaccine products for viral diseases such as rabies has necessitated the development of more sophisticated production techniques based around cell culture systems. This article reviews vaccine production strategies, with a focus on rabies, looking specifically at the use of the Vero cell line - used worldwide and approved by the US Food and Drug Administration - as well as media technology and the bioreactor options available.
Drug Research > Drug Discovery & Development > White Papers
31-45 of 149 results