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Drug Discovery & Development White Papers

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91-105 of 147 results
A short history of cell culture media and the use of insulin
| By Novo Nordisk Pharmatech A/S
The ancestors of cell culture media were the balanced salt solutions (BSS) devised by early workers interested in studying isolated organs ex vivo. The first BSS was composed in 1885 by Sydney Ringer (1836-1910), a British clinician and pharmacologist from University College London who worked on the isolated frog heart.
Drug Research > Drug Discovery & Development > White Papers
Introduction of Pierre de Meyts. MD, PhD, F.A.C.E
| By Novo Nordisk Pharmatech A/S
Pierre de Meyts is an expert who has worked with and researched insulin and receptor binding for almost half a century. FeF Chemicals A/S is proud to present what we assume to be one of the best pieces describing the functionality of insulin and insulin like growth factors, with respect to receptor binding and cellular response.
Drug Research > Drug Discovery & Development > White Papers
SOLUTIONS IN QUATS THAT FIT YOUR REQUIREMENTS cGMP Pharmaceutical Grade APIs & Excipients
| By Novo Nordisk Pharmatech A/S
FeF Chemicals is the worldwide leading supplier of high quality Quaternary Ammonium Compounds (quats). We are specialized in the pharmaceutical and personal care industries, providing quats of global regulatory compliance. We provide only the very best and safest ingredients for your formulation, preserving its quality and contributing to patient safety.
Drug Research > Drug Discovery & Development > White Papers
Smart HPLC Solutions for Large Molecules
| By Tosoh Bioscience
The biopharmaceutical research sector and its products represent a significant area of growth for today’s pharmaceutical industry. Major biotherapeutic categories currently include vaccines, therapeutic proteins such as growth factors or cytokines, and, last but not least, monoclonal antibodies. A thorough characterisation of these products is a key task for the successful submission of data for their regulatory approval.
Drug Research > Drug Discovery & Development > White Papers
TOYOPEARL gigaCap® Series
| By Tosoh Bioscience
ion exchange Chromatography (iEC) is one of the most frequently used chromatographic modes for the separation and purifi cation of biomolecules. it is used at all stages and scales of purifi cation of therapeutic proteins: from laboratory scale purifi cation to industrial scale downstream processing (dSP). toyopearl media are hydrophilic, macroporous polymethacrylate resins, available with various ligands and in different particle and pore sizes.
Drug Research > Drug Discovery & Development > White Papers
TOyOPEARl® AF-rProtein A-650F
| By Tosoh Bioscience
Protein A based affi nity chromatography is the industry standard for the capture of monoclonal antibodies (MAbs) in downstream processing. Affi nity media offer high selectivity thereby yielding a high purity of the target molecule in one step. The antibodies are captured at near neutral pH and eluted using acidic pH. The rising fermentation titres in the production of monoclonal antibodies drive the focus on developing resins that increase downstream capacity and effi ciency for these processes.
Drug Research > Drug Discovery & Development > White Papers
Direct analysis of biogenic amines in food by HILIC-MS
| By Tosoh Bioscience
Biogenic amines are present in protein-rich food such as fish, meat or milk. Their concentration increases during food decomposition. The reasons to monitor biogenic amines in food products are to determine that the food is suitable for consumption and to establish appropriate storage conditions.
Drug Research > Drug Discovery & Development > White Papers
Efficient SEC-UV-RI-MALS Analysis of Protein Aggregates
| By Tosoh Bioscience
Static light scattering in combination with size exclusion chromatography is a valuable tool for verifying purity of monoclonal antibodies (MABS) as such or as a quick check while the downstream processing takes place. Besides fluorescence detection, light scattering is one of the most sensitive methods to detect protein aggregates.
Drug Research > Drug Discovery & Development > White Papers
Analysis of Saccharides by HILIC using TSKgel® NH2-100 Columns
| By Tosoh Bioscience
Saccharides are fundametal substances that express various bioactivities and may exist independently or form complexes with proteins or lipids. They can be classified into monosaccharides, disaccharides, oligosaccharides, polysaccharides, based upon the degrees of polymerization and condensation.
Drug Research > Drug Discovery & Development > White Papers
Analysis of Water-Soluble Polymers Using Linear Size Exclusion HPLC Columns and a Semi-Micro SEC System
| By Tosoh Bioscience
In recent years water-soluble polymers are gaining more and more interest in different applications. The molecular weight distribution of polymers is usually characterized by size exclusion chromatography (SEC) coupled with refractive index, viscometric or laser light scattering detection. Recent advances in SEC comprise semi-micro SEC and the design of linear columns providing wide molecular weight separation ranges and near-linear calibrations.
Drug Research > Drug Discovery & Development > White Papers
CHARACTERIZING BIOTHERAPEUTICS WITH HPLC
| By Tosoh Bioscience
Development and production of biopharmaceuticals is a growing segment of pharmaceutical industry. Therapeutic proteins include blood factors, thrombolytic agents, growth factors, interferons, interleukins, therapeutic enzymes and last but not least monoclonal antibodies.
Drug Research > Drug Discovery & Development > White Papers
Reversed-Phase Analysis of Alkylbenzene Sulfonates
| By Tosoh Bioscience
Linear alkylbenzene sulfonates (LASs) are synthetic surfactants, which are produced by alkylation and sulfonation of benzene. LASs are a mixture of homologues and phenyl positional isomers, each containing an aromatic ring sulfonated at the para position and attached to a linear alkyl chain. The product is used in detergents and cleaning products for domestic and industrial use.
Drug Research > Drug Discovery & Development > White Papers
Characterisation Studies of PEGylated Lysozyme
| By Tosoh Bioscience
PEGylation, the process by which polyethylene glycol (PEG) chains are attached to protein and peptide drugs is a common practice in the development of biopharmaceuticals to prolong serum half-life and improve pharmacokinetics of a drug. There is increasing demand for chromatographic methods to separate the modified isoforms from the native protein.
Drug Research > Drug Discovery & Development > White Papers
91-105 of 147 results